Former Vice President Joe Biden is likely to be the main target for his presidential-primary rivals as he takes center stage this week in his first 2020 Democratic debate.

Mr. Biden will appear in Miami on Thursday in his third bid for the White House and first as front-runner—and as the most experienced debater in the 2020 campaign. The 76-year-old has participated in at least 16 debates as a presidential or vice-presidential candidate, but never before has he been the most susceptible to incoming attacks from multiple opponents.

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