The company said the train struck a dump truck at a public crossing near the city of Mendon at about 1:42 p.m. CT.
“There are approximately 243 passengers onboard with early reports of injuries,” company officials said. “Local authorities are currently assisting customers and we have deployed Amtrak resources to assist.”
Chillicothe Fire Department Chief Eric Reeter confirmed the derailment and said his department is on standby should authorities need them to assist.
No other details were available.
Mendon is about 100 miles northeast of Kansas City. The train was traveling from Los Angeles to Chicago.
The collision was the second in two days in which an Amtrak train hit a passenger vehicle. On Sunday, 85 passengers were on board a train in rural California that hit a vehicle. Three people were killed and two people suffered major injuries, according to officials. All of the victims were in the vehicle, the officials added.
This is a developing story and will be updated.